Healthy Eating Index and Breast Cancer Risk Among Malaysian Women

Shahril, Mohd Razif (2013) Healthy Eating Index and Breast Cancer Risk Among Malaysian Women. European Journal of Cancer Prevention, 22 (4). pp. 342-347. ISSN 0959-8278

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Abstract

Healthy Eating Index-2005 (HEI-2005), an index-based dietary pattern, has been shown to predict risk of chronic diseases among Americans. This study aims to examine the ability of HEI-2005 in predicting probability for risk of pre- and postmenopausal breast cancer among Malaysian women. Data from a case-control nutritional epidemiology study among 764 subjects comprising of 382 breast cancer cases and 382 healthy women were extracted and scored. Multivariate odds ratios (OR) with 95% confidence intervals (CI) were used to evaluate the relationship between risk of breast cancer and quartiles (Q) of HEI-2005 total scores and its component while the risk prediction ability of HEI-2005 was investigated using diagnostics analysis. Results of this study showed that there is a significant risk reduction of breast cancer risk with higher HEI-2005 total score among premenopausal women (ORQ1 vs. Q4=0.34, 95% CI; 0.15-0.76) and postmenopausal women (ORQ1 vs. Q4=0.20, 95% CI; 0.06-0.63). However, HEI-2005 has the sensitivity of 56-60%, specificity of 55-60%, positive predictive value and negative predictive value of 57-58%, which indicates moderate ability to predict risk of breast cancer according menopausal status. Observed breast cancer incidence poorly agrees with risk outcomes from HEI-2005 as shown by low Kappa statistics (k=0.15). In conclusion, although total HEI-2005 scores were associated with breast cancer risk among Malaysian women, the ability of HEI-2005 to predict risk is poor as indicated by the diagnostic analysis. A local index-based dietary pattern, which is disease-specific, is needed to predict risk of breast cancer among Malaysian women for early prevention.

Item Type: Article
Keywords: Breast cancer,dietary screening, healthy eating index, risk assessment
Subjects: R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Faculty / Institute: Faculty Of Health Sciences
Depositing User: Dr Mohd Razif Shahril
Date Deposited: 11 May 2014 06:45
Last Modified: 28 Apr 2015 04:33
URI: http://erep.unisza.edu.my/id/eprint/508

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