Effect of aqueous extract of Melastoma malabathricum leaves against paracetamol- and CCl4-induced liver toxicity in rats

Suhaili, Zarizal (2012) Effect of aqueous extract of Melastoma malabathricum leaves against paracetamol- and CCl4-induced liver toxicity in rats. African Journal of Pharmacy and Pharmacology, 6 (37). pp. 2682-2685. ISSN 1996-0816

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Abstract

Melastoma malabathricum L. Smith is a small shrub that belongs to the Melastomaceae family. Due toits high medicinal values,M. malabathricum has gained the herb status among Malaysian communities.The present study aimed to determine the potential hepatoprotective activity of aqueous extract of M.malabathricum leaves (AEMM) using rats models. Rats were divided into ten groups (n = 6)and received distilled water (dH2O) (negative control), 200 mg/kg silymarin (positive control) or AEMM (50,250 and 500 mg/kg) orally once daily for 7 days and on the 8th day subjected to the hepatotoxicinduction either using carbon tetrachloride (CCl4) or paracetamol (PCM). The blood and liver sampleswere collected and subjected to biochemical and microscopical analysis. Results indicated that theAEMM treated only at the dose of 500 mg/kg, exhibited significant (p <0.05) hepatoprotective activityagainst CCl 4- and PCM-induced liver toxicity model. These claimed are supported by the extract abilityto: i) reduce the plasma levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT),two of the liver enzymes that were increased in untreated hepatotoxic rats and ii) reduce histologicalscoring. The blood parameters findings were supported by histological observations. The leaves of M.malabathricum exert potential hepatoprotective activity, which could be attributed to its previouslyreported free radicals scavenging and antioxidant activities and high flavonoids content. Thus, in-depthstudies regarding the hepatoprotective activity of AEMM are required.

Item Type: Article
Keywords: elastoma malabathricum, Melastomaceae,in vivo, hepatoprotective activity, aqueous extract,leaves
Subjects: R Medicine > RS Pharmacy and materia medica
Faculty / Institute: Faculty of Bioresources & Food Industry
Depositing User: Zarizal Suhaili
Date Deposited: 11 Jun 2014 03:14
Last Modified: 11 Jun 2014 08:01
URI: http://erep.unisza.edu.my/id/eprint/493

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