The Role of Androgen under Normal and Pathological Conditions in Sebaceous Glands: The Possibility of Target Therapy

Abdullah, Azmahani and Nakamura, Yasuhiro and Keely M, McNamara and Hironobu, Sasano (2015) The Role of Androgen under Normal and Pathological Conditions in Sebaceous Glands: The Possibility of Target Therapy. Current Molecular Pharmacology, 9 (1). pp. 1-9. ISSN 1874-4672 (Print) 1874-4702 (Online)

[img] Text
Nakamura CMP 9-1-2016.pdf - Accepted Version
Restricted to Registered users only

Download (720Kb) | Request a copy
Official URL: http://europepmc.org/abstract/med/26159490

Abstract

The androgen receptor plays a pivotal role in the sebaceous glands. Its primary function is to stimulate cell proliferation and differentiation in the sebaceous and is association with acne. Previous studies have demonstrated expression of AR and steroidogenic enzymes in normal sebaceous glands and in all sebaceous disorders present evidence that androgen receptor may be a sensitive marker of sebaceous differentiation. It has been previously suggested that AR and steroidogenic enzymes immunohistochemistry may be useful particularly in identifying poorly sebaceous carcinoma. This review will provide an overview of the AR functions in the sebaceous glands and discussion of the therapeutic targets in acne and carcinoma.

Item Type: Article
Subjects: R Medicine > RB Pathology
Faculty / Institute: Faculty Of Health Sciences
Depositing User: Unnamed user with email azmahani@unisza.edu.my
Date Deposited: 14 Jul 2016 07:53
Last Modified: 14 Jul 2016 07:53
URI: http://erep.unisza.edu.my/id/eprint/4756

Actions (login required)

View Item View Item