Vitamin A, C, E and Risk of Breast Cancer According to Menopausal Status in Malaysia

Shahril, Mohd Razif and Syed Saadun Tarek Wafa, Sharifah Wajihah Wafa (2016) Vitamin A, C, E and Risk of Breast Cancer According to Menopausal Status in Malaysia. Malaysian Journal of Public Health Medicine , 16 (2). pp. 72-79. ISSN 1675-0306

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Abstract

Vitamin A, C and E intake has been shown to play a role in the etiology of breast cancer, but the findings have been inconsistent and limited to developed countries with higher cancer incidence. Therefore, the aim of this study is to examine the association of premenopausal and postmenopausal breast cancer risk with vitamin A, C and E intake from dietary sources. This is a population based case-control study conducted in Malaysian population among 382 breast cancer patients and 382 control group. Dietary intake was assessed via an interviewer-administered food frequency questionnaire. Logistic regression was used to compute odds ratios (OR) with 95% confidence intervals (CI) and a broad range of potential confounders were included in analysis. The results of this study shows a significant decreased risk of breast cancer among premenopausal (ORQ4 to Q1=0.38, 95% CI, 0.12 – 0.55, p-trend=0.001) and postmenopausal (ORQ4 to Q1=0.26, 95% CI, 0.03 – 0.75, p-trend=0.017) women was observed in the highest quartile of beta-carotene intake. Meanwhile, a higher intake of vitamin C showed significantly lowered risk only for premenopausal women (ORQ4 to Q1=0.13, 95% CI, 0.03 – 0.32, p-trend=0.001). As a conclusion, beta-carotene intake was independently related to pre- and postmenopausal breast cancer risk, while vitamin C intake was associated with decreased risk among premenopausal women only. However, no association was observed for vitamin A especially retinol and vitamin E intake from dietary sources.

Item Type: Article
Keywords: breast cancer, vitamin A, C, E, Malaysia, postmenopausal, premenopausal
Subjects: R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Faculty / Institute: Faculty Of Health Sciences
Depositing User: Dr Mohd Razif Shahril
Date Deposited: 06 Mar 2016 04:31
Last Modified: 06 Mar 2016 04:31
URI: http://erep.unisza.edu.my/id/eprint/4636

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