The AC/AG Diplotype for the 118A>G and IVS2 + 691G>C Polymorphisms of OPRM1 Gene is Associated with Sleep Quality Among Opioid Dependent Patients on Methadone Maintenance Therapy

Zahari, Zalina and Lee, Chee Siong and ibrahim, Muslih Abdulkarim and Musa, Nurfadhlina and Mohd Yasin, Mohd Azhar and Lee, Yeong Yeh and Tan, Soo Choon and Mohamad, Nasir and Ismail , Rusli (2016) The AC/AG Diplotype for the 118A>G and IVS2 + 691G>C Polymorphisms of OPRM1 Gene is Associated with Sleep Quality Among Opioid Dependent Patients on Methadone Maintenance Therapy. Pain and Therapy, 5 (1). pp. 1-12. ISSN 2193-651X

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Abstract

Introduction: Methadone is a full agonist of the opioid receptor mu 1 which is encoded by the OPRM1 gene. Sleep disorders were frequently reported by opioid-dependent patients during methadone maintenance therapy (MMT). It is possible, therefore, that genetic polymorphisms in OPRM1 influence sleep quality among patients on MMT. This study investigated the association of OPRM1 polymorphisms with sleep quality among opioid-dependent patients on MMT. Methods: The sleep quality of 165 male opioid-dependent patients receiving MMT was evaluated using the Pittsburgh Sleep Quality Index (PSQI). DNA was extracted from whole blood and subjected to polymerase chain reaction (PCR) genotyping. Results: Patients with IVS2 ? 691 CC genotype had higher PSQI scores [mean (SD) = 5.73 (2.89)] compared to those without the IVS2 ? 691 CC genotype (IVS2 ? 691 GG/GC

Item Type: Article
Keywords: AC/AG diplotype; Male patients; Methadone; Methadone maintenance therapy; Opioid dependence; Opioid receptor; Opioid receptor, mu 1 gene; OPRM1; Pittsburgh Sleep Quality Index; Sleep quality
Subjects: Q Science > QP Physiology
R Medicine > R Medicine (General)
Faculty / Institute: Faculty of Medicine
Depositing User: Prof.Dr Nasir Mohamad
Date Deposited: 10 Feb 2016 02:33
Last Modified: 10 Feb 2016 02:33
URI: http://erep.unisza.edu.my/id/eprint/4522

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