Tualang honey supplementation improves oxidative stress status among chronic smokers

Wan Syaheedah , Wan Ghazali and Mahaneem, Mohamed and Siti Amrah, Sulaiman and Abd Aziz, Aniza and Mohd Yusoff, Harmy (2015) Tualang honey supplementation improves oxidative stress status among chronic smokers. Toxicological & Environmental Chemistry, 97 (8). pp. 1017-1024. ISSN 0277-2248 (Print) 1029-0486 (Online)

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Free radicals induced by cigarette smoking have been linked to an increase in oxidative stress resulting in smoking-related cardiovascular diseases. However, the possible effect of honey that has antioxidant property in improving oxidative stress status among smokers has not yet been reported. Hence, this study was to determine the effects of 12-week Tualang honey supplementation on F2-isoprostanes, superoxide dismutase, glutathione peroxidase, catalase, and total antioxidant status among chronic smokers. A total of 32 non-smokers and 64 chronic smokers were recruited from Quit Smoking Clinic and Health Campus, Universiti Sains, Malaysia. Smokers were randomized into two groups (n D 32/group) namely smokers without supplementation and smokers with honey supplementation (20 g/day) for 12 weeks. Blood was obtained from non-smokers and smokers at pre-intervention and from smokers at post-intervention. During pre-intervention, the levels/activity of F2- isoprostanes, total antioxidant status, and catalase were significantly higher while superoxide dismutase and glutathione peroxidase were lower in smokers than nonsmokers. During post-intervention, in supplemented smokers, there were significant decrease in F2-isoprostanes and increase in total antioxidant status, glutathione peroxidase and catalase levels/activities compared with pre-intervention. This study indicates that honey supplementation improves oxidative stress status suggesting a beneficial role of honey in reducing the risk of cardiovascular diseases. Keywords: cigarette smoking; oxidative stress; Tualang honey; antioxidant; smokers

Item Type: Article
Subjects: Q Science > Q Science (General)
R Medicine > R Medicine (General)
R Medicine > RZ Other systems of medicine
Faculty / Institute: Faculty of Medicine
Depositing User: AP Dr Aniza Abd Aziz
Date Deposited: 27 Dec 2015 02:50
Last Modified: 27 Dec 2015 02:50
URI: http://erep.unisza.edu.my/id/eprint/4176

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