Opioid dependence and substitution therapy: thymoquinone as potential novel supplement therapy for better outcome formethadone maintenance therapy substitution therapy

Mohd Adnan, Liyana Hazwani and Abu Bakar, Nor Hidayah and Mohamad, Nasir (2014) Opioid dependence and substitution therapy: thymoquinone as potential novel supplement therapy for better outcome formethadone maintenance therapy substitution therapy. Iranian Journal of Basic Medical Sciences , 17. pp. 926-928. ISSN 2008-3866

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Abstract

Methadone is widely being used for opioid substitution therapy. However, the administration of methadone to opioid dependent individual is frequently accompanied by withdrawal syndrome and chemical dependency develops. Other than that, it is also difficult to retain patients in the treatment programme making their retention rates are decreasing over time. This article is written to higlights the potential use of prophetic medicines, Nigella sativa, as a supplement for opioid dependent receiving methadone. It focuses on the potential role of N. sativa and its major active compound, Thymoquinone (TQ) as a calcium channel blocking agent to reduce withdrawal syndrome and opioid dependency.

Item Type: Article
Keywords: Calcium channel blocker Methadone Nigella sativa Opioid dependence Thymoquinone
Subjects: R Medicine > RZ Other systems of medicine
Faculty / Institute: Faculty of Medicine
Depositing User: Dr Nor Hidayah Abu Bakar
Date Deposited: 28 Oct 2015 07:22
Last Modified: 28 Oct 2015 07:22
URI: http://erep.unisza.edu.my/id/eprint/3825

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