Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death

Narayanan, Kannan Badri and Ali, Manaf and Barclay, Barry J and Cheng, Qiang and D’Abronzo, Leandro and Dornetshuber-Fleiss, Rita and M.Ghosh, Paramita and Guzman, Michael J.Gonzalez and Lee, Tae-Jin and Leung, Po Sing and Li, Lin and Luanpitpong, Suidjit and Ratovitski, Edward and Rojanasakul, Yon and Romano, Maria Fiammetta and Romano, Simona and Sinha, Ranjeet Kumar and Yedjou, Clement and Al-Mulla, Fahd and Al-Temaimi, Rabeah and Amedei, Amedeo and G.Brown, Dustin and P.Ryan, Elizabeth and Colacci, Annamaria and A.Hamid, Roslida and Mondello, Chiara and Raju, Jayadev and K.Salem, Hosni and Woodrick, Jordan and Scovassi, Ivana and Singh, Neetu and Vaccari, Monica and Roy, Rabindra and Forte, Stefano and Memeo, Lorenzo and Kim, Seo Yun and H.Bisson, William and Lowe, Leroy and Park, Hyun Ho (2015) Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death. CARCINOGENESIS, 36 (S1). S89-S110. ISSN 0143-3334 (Printed) 1460-2180 (Online)

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Abstract

Cell death is a process of dying within biological cells that are ceasing to function. This process is essential in regulating organism development, tissue homeostasis, and to eliminate cells in the body that are irreparably damaged. In general, dysfunction in normal cellular death is tightly linked to cancer progression. Specifically, the up-regulation of prosurvival factors, including oncogenic factors and antiapoptotic signaling pathways, and the down-regulation of proapoptotic factors, including tumor suppressive factors, confers resistance to cell death in tumor cells, which supports the emergence of a fully immortalized cellular phenotype. This review considers the potential relevance of ubiquitous environmental chemical exposures that have been shown to disrupt key pathways and mechanisms associated with this sort of dysfunction. Specifically, bisphenol A, chlorothalonil, dibutyl phthalate, dichlorvos, lindane, linuron, methoxychlor and oxyfluorfen are discussed as prototypical chemical disruptors; as their effects relate to resistance to cell death, as constituents within environmental mixtures and as potential contributors to environmental carcinogenesis.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Faculty / Institute: Faculty of Bioresources & Food Industry
Depositing User: Prof Dr Abd Manaf Ali
Date Deposited: 26 Aug 2015 00:46
Last Modified: 26 Aug 2015 00:46
URI: http://erep.unisza.edu.my/id/eprint/3517

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