Comparative analysis of the antibacterial, antifungal, antiproliferative and cyclic response element (CRE) induced expression of downstream luc gene activities of Monopterus albus and Channa straitus extracts

Baig, Atif Amin and Zahri @ Johari, Mohd Khairi and Esa, Abdul Rahman and BA, Zilfalil and Simbak, Nordin (2015) Comparative analysis of the antibacterial, antifungal, antiproliferative and cyclic response element (CRE) induced expression of downstream luc gene activities of Monopterus albus and Channa straitus extracts. Journal of Applied Pharmaceutical Science, 5 (1). pp. 42-47. ISSN 2231-3354

[img] Text
1411_pdf.pdf - Published Version
Restricted to Registered users only

Download (263Kb) | Request a copy
Official URL: http://www.japsonline.com/past-articles.php?issuei...

Abstract

In Malaysia, Monopterus albus is commonly found in rice fields, muddy ponds and swamp areas. Channa striatus have been widely used as a source of traditional medicines. The extracts of Malaysian local Monopterus albus and Channa straitus have been reported to have different bioactive properties and these properties can be used at molecular level as alternative tool for different disorders. The comparative analysis of antibacterial, antifungal, antiproliferative and CRE induced expression of downstream luc gene activities of both the extracts were performed. The bacteriostatic and antibacterial effects of both extracts were revealed beside higher antifungal activity of Channa straitus. The extracts from Monopterus albus showed higher levels of antiproliferative activity as compare to Channastraitus. The results were found supportive towards up regulation of hrluc by Monopterus albus extracts and down regulation by Channa striatus extracts. This is the first report on comparing the bioactive properties of Monopterus albus and Channa straitus. The results from this study demands a further research on identifying the bioactive molecules involve in these actions at a molecular level.

Item Type: Article
Subjects: R Medicine > RM Therapeutics. Pharmacology
Faculty / Institute: Faculty of Medicine
Depositing User: Dr Atif Baig
Date Deposited: 24 Mar 2015 07:29
Last Modified: 27 Apr 2015 02:48
URI: http://erep.unisza.edu.my/id/eprint/3134

Actions (login required)

View Item View Item