Evaluation Of Antimitotic Activity Of Solanum Torvum Using Allium Cepa Root Meristamatic Cells And Anticancer Activity Using MCF-7- Human Mammary Gland Breast Adenocarcinoma Cell Lines

U.S , Mahadeva Rao and A., Thenmozhi (2011) Evaluation Of Antimitotic Activity Of Solanum Torvum Using Allium Cepa Root Meristamatic Cells And Anticancer Activity Using MCF-7- Human Mammary Gland Breast Adenocarcinoma Cell Lines. Drug Invention Today, 3 (12). pp. 290-296. ISSN 0975-7619

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Abstract

Objective: An attempt has been made to evaluate the antimitotic activity of Solanum torvum. The studies were extended to human cells using MCF-7- Human mammary gland breast adenocarcinoma cell lines. Methods: Preliminary antimitotic screening was done using Allium cepa root tip assay. The herbal powder obtained from various plant parts-dry leaves, dry fruits and fresh fruits were extracted with various solvents. The antimitotic activity was analysed using Allium cepa root meristematic cells. Experiments were carried out with incorporation of folic acid in the extract. Folic acid inhibited the antimitotic activity of S.torvum extract. Findings: The results obtained were compared with methotrexate-a known anticancer drug. Extracts of S.torvum was found to be extremely effective in the prevention of cell proliferation of the mammary gland breast adenocarcinoma cell lines. Discussion: The pronounced antimitotic and anticancer activities of S.torvum was due to its potential antioxidant property especially by the key role of phytochemicals such as polyphenols, steroidal saponin glycoside, alkaloids and flavonoids. Active principle sterol has been separated by TLC. Conclusion: These findings suggest that the promising antioxidant properties of the plant could be exploited in herbal preparations against oxidative stress, ageing, Ischemic heart disease in dissolving thrombus, microbial infections, hormone replacement therapy (HRT) and cancer justifying their use in traditional medicine. Keywords: Solanum torvum; Allium cepa; Anticancer; Mammary carcinoma fibroblast MCF-7 cell lines; Antimitotic

Item Type: Article
Subjects: R Medicine > RZ Other systems of medicine
Faculty / Institute: Faculty of Medicine
Depositing User: Dr U.S.Mahadeva Rao
Date Deposited: 08 Feb 2015 04:35
Last Modified: 28 Apr 2015 06:49
URI: http://erep.unisza.edu.my/id/eprint/2249

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