Comparative Biochemical Evaluation of Hypoglycemic and Free Radical Scavenging activities of Noni and Spirulina in Streptozotocin-Induced Diabetic Rat Tissues

U.S , Mahadeva Rao and R., Babujanarthanam and R., Balabhaskar (2011) Comparative Biochemical Evaluation of Hypoglycemic and Free Radical Scavenging activities of Noni and Spirulina in Streptozotocin-Induced Diabetic Rat Tissues. Journal of Pharmacy Research, 4 (10). pp. 3630-3634. ISSN 2319-5622

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Abstract

The present study was aimed to investigate the hypoglycemic property and free radical scavenging activity (FRSA) of aqueous extracts of Noni fruit and Spirulina evaluated in Streptozotocin (STZ) induced diabetic rat tissues. Dosage : The Noni fruit and Spirulina aqueous extracts at a concentration of 300mg and 15mg /kg of body weight/rat/day respectively was orally administrated to STZ –induced diabetic rats for a period of 30 days. Methods: The blood glucose, plasma insulin, glycosylated hemoglobin, serum creatinine, and blood urea estimations were carried out. Histopathological studies were done in pancreatic tissues. Lipid peroxidation as well as anti-oxidant activity (enzymatic and non-enzymatic) assays were performed. Results and Discussion: The elevated levels of blood glucose, glycosylated hemoglobin, serum creatinine, and blood urea and diminished concentration of insulin in diabetic rats reverted back to near normal after treatment with aqueous extracts. Histopathological studies of the pancreas showed the protective role of Noni and Spirulina aqueous extracts. Elevation of Lipid peroxidation products and depletion of anti-oxidant activity in diabetic rats reverted back to near normal after treatment with aqueous extracts confirm the potent FRSA. Conclusion: From the comparative observation, it was hypothesized that aqueous extract of Noni fruit shows more effective antidiabetic property as well as diminished lipid peroxidation and elevated anti-oxidant activity than Spirulina extract. Both the extracts were compared with reference drug Metformin. Keywords: Noni, Spirulina, Metformin, Streptozotocin, Diabetes mellitus.

Item Type: Article
Subjects: R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Faculty / Institute: Faculty of Medicine
Depositing User: Dr U.S.Mahadeva Rao
Date Deposited: 08 Feb 2015 04:26
Last Modified: 28 Apr 2015 06:50
URI: http://erep.unisza.edu.my/id/eprint/2244

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