Elevated Singlet Oxygen Dependent Tissue Injury As Well As Diminished Activity of Antioxidative Defense Mechanism by Sodium Valproate Clinical Course in Epileptic Children

U.S , Mahadeva Rao and Sangeetha, N. (2011) Elevated Singlet Oxygen Dependent Tissue Injury As Well As Diminished Activity of Antioxidative Defense Mechanism by Sodium Valproate Clinical Course in Epileptic Children. Research Journal Of Pharmacology and Pharmacodynamics, 3 (6). pp. 307-310. ISSN 0975-4407

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Abstract

The study was aimed to determine the biochemical changes in the free radical profile and antioxidant enzyme status in epileptic children before and after treatment with VPA monotherapy. Methods: We have studied the levels of serum LPO (MDA), erythrocyte antioxidants (GSH, GPx, SOD and CAT) in 25 epileptic children before and after treatment with sodium valproate and compared them against 25 healthy children. Results: The results showed that MDA levels were increased (p<0.001) in epileptic children under VPA treatment compared to the controls. Antioxidant enzymes GPx, SOD, CAT activities were decreased (p<0.001) in epileptic children receiving VPA monotherapy whereas no significant changes when compared between before and after treatment with VPA. The level of GSH was also decreased (p<0.001) in follow-up cases of epileptic children receiving VPA therapy. Conclusion: It was hypothesized that the oxidantsantioxidants balance were modified further by sodium valproate in epileptic children. KEY-WORDS: Sodium valproate, antioxidants, lipid peroxidation, oxidative stress, epilepsy, free radical

Item Type: Article
Subjects: R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
Faculty / Institute: Faculty of Medicine
Depositing User: Dr U.S.Mahadeva Rao
Date Deposited: 08 Feb 2015 04:12
Last Modified: 28 Apr 2015 06:50
URI: http://erep.unisza.edu.my/id/eprint/2240

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