Cytotoxic and Anti-Tumour Promoting Activities of Carbazole Alkaloids from Malayan Murraya koenigii (L.) Spreng

Ahmad, Kartini and Tan, Siow-Ping and Sukari, Mohd Aspollah and Ali, Abd Manaf and Nafiah, Mohd Azlan (2014) Cytotoxic and Anti-Tumour Promoting Activities of Carbazole Alkaloids from Malayan Murraya koenigii (L.) Spreng. American Journal of Plant Sciences, 5 (2014). pp. 2869-2877. ISSN 2158-2742 (Printed) 2158-2750 (Online)

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Abstract

Murraya koenigii (L.) (Rutaceae) is an indigenous medicinally important herb of Indian origin and now is widely distributed throughout southern Asia. The stem bark, leaves and roots of Malayan Murraya koenigii were selected for phytochemical investigation. Eight carbazole alkaloids was isolated and identified using spectroscopic methods including NMR, IR, UV, MS spectra data. Crude extract and isolated compounds from the roots of this plant were screened for cytotoxic activity and antitumor promoting activity. All crude extracts of the roots including the isolated compounds,mahanimbine, mahanine and murrayafoline-A exhibited significant cytotoxic activity against CEM-SS cell line with IC50 3 μg/mL. Girinimbine inhibited EBV-activation in the antitumor promoting assay.

Item Type: Article
Subjects: Q Science > QD Chemistry
Faculty / Institute: Faculty of Bioresources & Food Industry
Depositing User: Prof Dr Abd Manaf Ali
Date Deposited: 23 Dec 2014 07:14
Last Modified: 23 Dec 2014 07:14
URI: http://erep.unisza.edu.my/id/eprint/2118

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