Insulin Stimulative and Anti-Oxidative Effects of Persea americana Fruit Extract on Streptozotocin Induced Hyperglycemic Rats

Rao , U.S. Mahadeva and Haque , Mainul and Baig, Atif Amin (2011) Insulin Stimulative and Anti-Oxidative Effects of Persea americana Fruit Extract on Streptozotocin Induced Hyperglycemic Rats. Journal of Medical and Biological Sciences, 4 (1). pp. 1-10. ISSN 1934-7189

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Abstract

The insulin stimulative and antioxidative effect of Persea americana fruits extract were evaluated in streptozotocin (STZ). The ethanolic extract of P.americana at a concentration of 300mg/kg body weight/rat/day was orally administered to STZ-induced hyperglycemic rats for a period of 30 days. The elevated levels of blood glucose, glycosylated hemoglobin, blood urea, and serum creatinine in the hyperglycemic rats reverted back to near normal after treatment with the avocado fruit extract. Similarly significant decreases in the levels of plasma insulin and the hemoglobin were elevated to near normal after treatment with fruit extract, suggesting the insulin stimulative effect of P.americana fruit. Determination of thiobarbituric acid reactive substance (TBARS), hydroperoxides, and both enzymatic and nonenzymatic antioxidant evidenced the antioxidative potential of the extract of avocado fruit, which in turn may be responsible for its hypoglycemic potential. Alterations observed in the activities of pathophysiological enzymes such as serum aspartate transaminase (AST), serum alanine transaminase (ALT), and serum alkaline phosphatase (ALP) in the serum of control and experimental groups of rats revealed the tissue protective nature of Persea americana fruits in comparison with glyclazide, the standard reference drug.

Item Type: Article
Keywords: -
Subjects: R Medicine > RS Pharmacy and materia medica
Faculty / Institute: Faculty of Medicine
Depositing User: Professor Dr Mainul Haque
Date Deposited: 20 Jan 2015 04:51
Last Modified: 28 Apr 2015 06:43
URI: http://erep.unisza.edu.my/id/eprint/1916

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