Spinal Muscular Atrophy; A Molecular Insight: Molecular atrophies and promoter region of SMN genes

Baig, Atif Amin and Zin , Thant and A. Latif, Ahmad Zubaidi and Alwi, Zilfalil (2013) Spinal Muscular Atrophy; A Molecular Insight: Molecular atrophies and promoter region of SMN genes. 1, 1 (1). Creatspace, USA. ISBN 978-1479179541

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Abstract

Spinal muscular atrophy (SMA) is an autosomal disease which is one of the leading genetic causes of infant deaths. The cause of the SMA is degeneration of motor neurons of spinal cord. The incidence of SMA is about one in 10, 000 live births with a carrier frequency of one in 50 to one in 35. The SMA’s frequency in Caucasians is reported to be 1 in 18,000 births, in Japanese it is reported to be 1 in 10,000 births, in Americans it is reported to be 1 in 6000 births. This book explains well the underlying molecular mechanisms involve in inducing and modifying the SMA. This book is dedicated to all SMA patients and the researchers. The authors have been involved in ongoing research projects regarding genetics and epigenetics of SMA. The difficulties in understanding the basic pathogenesis and pathology of SMA makes the authors realize to write a chapter as a part of the doctorate thesis which is compiled in this present form.

Item Type: Book
Subjects: R Medicine > RB Pathology
Faculty / Institute: Faculty of Medicine
Depositing User: Dr Atif Baig
Date Deposited: 07 Jan 2015 02:36
Last Modified: 27 Apr 2015 08:11
URI: http://erep.unisza.edu.my/id/eprint/1800

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