ACE2 activation by xanthenone prevents leptin-induced increases in blood pressure and proteinuria during pregnancy in Sprague-Dawley rats

Al-Shaikhli, Hisham S Ibrahim and Anisah Froemming, Gabrielle Ruth and Omar, Effat and Singh, Harbindar Jeet (2014) ACE2 activation by xanthenone prevents leptin-induced increases in blood pressure and proteinuria during pregnancy in Sprague-Dawley rats. Reproduction Toxicology, 49. pp. 155-161. ISSN 0890-6238

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Abstract

investigates the effect of ACE2 activation on leptin-induced changes in systolic blood pressure (SBP),proteinuria, endothelial activation and ACE2 expression during pregnancy in Sprague-Dawley rats.Pregnant rats were given subcutaneous injection of either saline, or leptin, or leptin plus Xanthenone (ACE2 activator), or xanthenone (XTN) alone. SBP, serum ACE, ACE2, endothelin-1, E-selectin and ICAM-1 levels were estimated; also their gene expressions were determined in the kidney and aorta respectively. Compared to control, SBP was higher in the leptin-only treated group (P < 0.001) and lower in rats treated with xanthenone alone (P < 0.01). Proteinuria, markers of endothelial activation were significantly higher than controls in leptin-only treated rats (P < 0.05). ACE2 activity and expression were lower in leptinonly treated rats when compared to controls (P < 0.05). It seems, leptin administration during pregnancy significantly increases SBP, proteinuria, endothelial activation, but decreases ACE2 level and expression.These effects are prevented by concurrent administration of xanthenon

Item Type: Article
Subjects: Q Science > QP Physiology
Faculty / Institute: Faculty of Medicine
Depositing User: Dr Hisham S Ibrahim Al-Shaikhli
Date Deposited: 17 Nov 2014 03:37
Last Modified: 27 Apr 2015 03:26
URI: http://erep.unisza.edu.my/id/eprint/1787

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