Mohd, Khamsah Suryati and Azemin, Azierah and Rosli, Ainul Syamira and Dharmaraj, Saravanan and Hamdan, M. R and Ismail, Zhari and Mat, Nashriyah (2014) DOES VARIETY MATTERS FOR THERAPEUTIC APPLICATION OF FICUS DELTOIDEA JACK? In: International Conference on Natural Product 2014, 18-19 March, Palm Garden Hotel, IOI Resort, Putrajaya.

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Proper identification of the source plant with related biological property is fundamental in herbal standardization. Ficus deltoidea Jack (FD), a South East Asian native plant traditionally used to treat several diseases and pharmacologically tested to posses several biological activities. However, there is confusion on the identification of plant material as FD occurs at least in eight varieties namely Ficus deltoidea var. deltoidea, var. trengganuensis, var. kunstleri, var. motleyana, var. intermedia, var. bornensis, var. bilobata and var. angustifolia. Since reports on pharmacological and chemical studies were not at the varietal level, it is difficult to identify the best variety to be commercialized. In order to characterize the differences between varieties in terms of chemical profiles, eight varieties of FD were collected from several localities around Malaysian Peninsular and Borneo and subjected to HPTLC and FTIR fingerprinting analysis. The C-linked flavone glycosides, vitexin and isovitexin served as markers. HPTLC chromatograms indicate differences in chemical profile among varieties. Quantitative HPTLC-densitometric showed that FD var. deltoidea contains the highest amount of vitexin (15.64 ng/µg, R2= 0.990) and FD var. bornensis posses the most amount of isovitexin (11.73 ng/µg, R2= 0.960). Analysis on unsupervised FTIR data using principal component analysis (PCA) found that all eight varieties clusters into eight different groups where PC1 show 86% are near to the axis of the origin indicating that they were from the same species but differ at some point between varieties. Based of HPTLC-densitometric quantification and chemometric analysis on FTIR spectra, chemical composition of F. deltoidea varieties was significantly different from each other. Finding from this study will assist the selection of the best variety to developed further as herbal medicine.

Item Type: Conference or Workshop Item (Poster)
Subjects: R Medicine > RS Pharmacy and materia medica
Faculty / Institute: Faculty of Bioresources & Food Industry
Depositing User: Dr Khamsah Suryati Mohd
Date Deposited: 19 Oct 2014 09:43
Last Modified: 19 Oct 2014 09:43

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