Minimal Modeling of Glucose-Insulin Interactions in the Intravenous Glucose Tolerance Test

Ab Kahar, Kamariah Noor and Mamat, Mustafa and Salleh, Zabidin and Zakaria, Zahratul Amani (2014) Minimal Modeling of Glucose-Insulin Interactions in the Intravenous Glucose Tolerance Test. Applied Mathematical Sciences, 8 (66). pp. 3273-3281. ISSN 1314-7552 , e-ISSN : 1312-885X

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Official URL: http://dx.doi.org/10.12988/ams.2014.4299

Abstract

The minimal model of glucose and insulin plasma levels is commonly used to analyze the results of glucose tolerance tests in humans. In this paper, a mathematical model for describing the glucose infusion rate was introduced. The minimal model was used to study a few sets of published data including healthy humans and type 2 diabetes. The glucose-insulin system as a dynamic integrated physiological system and generated the real optimized model parameters from the experimental data using the modified minimal model. The averaged R2 value between measured and calculated plasma concentrations wais 0.977, which indicates excellent agreement.

Item Type: Article
Keywords: Minimal model, Intravenous glucose tolerance test, Glucose-insulin system
Subjects: Q Science > Q Science (General)
Q Science > QA Mathematics
Faculty / Institute: Faculty of Informatics & Computing
Depositing User: Dr Zahrahtul Amani Zakaria
Date Deposited: 03 Nov 2014 00:38
Last Modified: 05 Mar 2015 06:40
URI: http://erep.unisza.edu.my/id/eprint/1526

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